Cowpea chlorotic mottle virus (CCMV) is a spherical plant virus with a diameter of 28 nm. Its protein capsid consists of 180 identical proteins which protect the RNA genome of the virus. When the RNA is removed, the proteins can reversibly assemble into a capsid under controlled conditions with respect to pH and ionic strength. This capsid has the same well-defined size and shape as the wildtype virus and is the subject of this project.
The CCMV capsid can be used to encapsulate useful molecules, such as enzymes and catalysts. Because of its well-defined size and shape it can also be used as a scaffold for new materials. To increase the potential of the CCMV capsid, we want to introduce selective functional handles into the protein. These can be used to attach enzymes, catalysts, polymers or other molecules to the inner or outer surface of the capsid.
Three student projects are available:
Nolte group for physical-organic and supramolecular chemistry
