Virusses and bio-hybrid systems

Cowpea chlorotic mottle virus (CCMV) is a spherical plant virus with a diameter of 28 nm. Its protein capsid consists of 180 identical proteins which protect the RNA genome of the virus. When the RNA is removed, the proteins can reversibly assemble into a capsid under controlled conditions with respect to pH and ionic strength. This capsid has the same well-defined size and shape as the wildtype virus and is the subject of this project.

Subprojects:

Marta Comellas Aragonès Marta Comellas Aragonès Phone: 52174	no title yet
A. (Ton) J. Dirks A. (Ton) J. Dirks Phone: 52174	no title yet
Andrés de la Escosura Navazo Andrés de la Escosura Navazo Phone:	Protein cages as nanoreactors for the synthesis of polymers and biohybrid materials
Linda Hendriks Linda Hendriks Phone: 52174	Selective functionalization of virus capsids
Inge J. Minten Inge J. Minten Phone: 52028	no title yet
Friso D. Sikkema Friso D. Sikkema Phone: 52174	no title yet

• Marta Comellas-Aragonès, Hans Engelkamp, Victor I. Claessen, Nico A. J. M. Sommerdijk, Alan E. Rowan, Peter C. M. Christianen, Jan C. Maan, Benedictus J. M. Verduin, Jeroen J. L. M. Cornelissen & Roeland J. M. Nolte, A virus-based single-enzyme nanoreactor, Nature Nanotechnology, 2, 10, 635-639 (2007).
  PDF doi:10.1038/nnano.2007.299
  
  
• F.D. Sikkema, M. Comellas-Aragones, R.G. Fokkink, B.J.M Verduin, J.J.L.M. Cornelissen, R.J.M. Nolte, Monodisperse Polymer-Virus Biohybrid Nanoparticles, Org. Biom. Chem., 5, 54-57 (2007).
  PDF doi:10.1039/b613890j
  
  
• D.M. Vriezema, M. Comellas Aragonés, J.A.A.W. Elemans, J.J.L.M. Cornelissen, A.E. Rowan, R.J.M. Nolte, Self-Assembled Nanoreactors, Chemical Reviews, 36, 32, 1445-1489 (2005).
  PDF doi:10.1021/cr0300688