Research New synthetic methodology Bio and transition metal catalysis Total synthesis of bioactive natural products Hyperbaric synthesis Synthesis-on-a-Chip Total synthesis of natural compounds In recent years, we have been involved in a variety of target-oriented projects aimed at the total synthesis of natural products with potentially interesting biological activity such as epibatidine, febrifugine, quinolizidine 233A and epiquinamide. In addition, a substantial target-oriented project focuses on approaches to optimize the antibiotic properties of neomycin (one of the aminoglycoside antibiotics) via the synthesis of libraries of conformationally restricted neamine derivatives.